{"id":13243,"date":"2023-09-08T14:37:33","date_gmt":"2023-09-08T07:37:33","guid":{"rendered":"http:\/\/12point.net\/?p=13243"},"modified":"2023-09-08T14:37:33","modified_gmt":"2023-09-08T07:37:33","slug":"thong-tin-thuoc-thang-09-2023","status":"publish","type":"post","link":"https:\/\/12point.net\/thong-tin-thuoc-thang-09-2023\/","title":{"rendered":"TH\u00d4NG TIN THU\u1ed0C TH\u00c1NG 09\/2023"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>MHRA: VALPROAT \u2013 L\u01afU \u00dd V\u1ec0 C\u00c1C Y\u00caU C\u1ea6U HI\u1ec6N H\u00c0NH C\u1ee6A CH\u01af\u01a0NG TR\u00ccNH D\u1ef0 PH\u00d2NG CHO THAI K\u1ef2, TH\u00d4NG TIN V\u1ec0 C\u00c1C BI\u1ec6N PH\u00c1P \u0110\u1ea2M B\u1ea2O AN TO\u00c0N M\u1edaI S\u1ebc \u0110\u01af\u1ee2C C\u1eacP NH\u1eacT TRONG TH\u1edcI GIAN T\u1edaI<\/strong><\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-family: 'times new roman', times, serif;\">DS Nguy\u1ec5n Th\u1ecb Thanh B\u00ecnh &#8211; K. D\u01b0\u1ee3c<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><em>Tr\u01b0\u1edbc nh\u1eefng d\u1eef li\u1ec7u v\u1ec1 an to\u00e0n c\u1ee7a ph\u01a1i nhi\u1ec5m v\u1edbi valproat trong thai k\u1ef3, b\u00e0i vi\u1ebft n\u00e0y l\u01b0u \u00fd v\u1edbi nh\u00e2n vi\u00ean y t\u1ebf v\u1ec1 nh\u1eefng nguy c\u01a1 c\u00f3 th\u1ec3 x\u1ea3y ra trong th\u1eddi k\u1ef3 mang thai v\u00e0 c\u00e1c y\u00eau c\u1ea7u hi\u1ec7n h\u00e0nh c\u1ee7a Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3. \u0110\u1ed3ng th\u1eddi cung c\u1ea5p th\u00f4ng tin v\u1ec1 nh\u1eefng nguy c\u01a1 ti\u1ec1m \u1ea9n \u1edf nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n kh\u00e1c c\u00f3 d\u00f9ng valproat sau khi \u0111\u00e1nh gi\u00e1 d\u1eef li\u1ec7u c\u1eadp nh\u1eadt v\u1ec1 an to\u00e0n thu\u1ed1c. Theo khuy\u1ebfn c\u00e1o c\u1ee7a U\u1ef7 ban thu\u1ed1c s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi (CHM), c\u00e1c bi\u1ec7n ph\u00e1p \u0111\u1ea3m b\u1ea3o an to\u00e0n m\u1edbi \u0111\u1ed1i v\u1edbi thu\u1ed1c ch\u1ee9a valproat s\u1ebd \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong th\u1eddi gian t\u1edbi.\u00a0<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><em>CHM \u0111\u00e3 th\u00e0nh l\u1eadp m\u1ed9t nh\u00f3m li\u00ean ng\u00e0nh y t\u1ebf \u0111\u1ec3 h\u1ed7 tr\u1ee3 vi\u1ec7c \u1ee9ng d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p \u0111\u1ea3m b\u1ea3o an to\u00e0n m\u1edbi v\u00e0o th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng th\u00f4ng qua m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh ph\u00e1t tri\u1ec3n t\u1eebng b\u01b0\u1edbc d\u1ef1a tr\u00ean nh\u1eefng l\u1ef1a ch\u1ecdn \u01b0u ti\u00ean v\u1ec1 an to\u00e0n cho b\u1ec7nh nh\u00e2n. Ch\u01b0\u01a1ng tr\u00ecnh c\u00f3 s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a c\u00e1c c\u01a1 quan ch\u0103m s\u00f3c s\u1ee9c kho\u1ebb \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o vi\u1ec7c ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n li\u00ean t\u1ee5c kh\u00f4ng b\u1ecb gi\u00e1n \u0111o\u1ea1n. \u00a0<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><em>Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng valproat kh\u00f4ng \u0111\u01b0\u1ee3c t\u1ef1 \u00fd ng\u1eebng thu\u1ed1c tr\u1eeb khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa. Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n nghi ng\u1edd mang thai khi \u0111ang d\u00f9ng valproat n\u00ean ngay l\u1eadp t\u1ee9c trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 chuy\u00ean khoa.\u00a0\u00a0<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\"><em>Tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng valproat cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 55 tu\u1ed5i, nh\u00e2n vi\u00ean y t\u1ebf c\u1ea7n ph\u1ea3i c\u00e2n nh\u1eafc t\u1ea5t c\u1ea3 c\u00e1c l\u1ef1a ch\u1ecdn thu\u1ed1c \u0111\u1ed9ng kinh thay th\u1ebf kh\u00e1c v\u00e0 tham kh\u1ea3o \u0111\u00e1nh gi\u00e1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ch\u00fang \u0111\u1ed1i v\u1edbi thai k\u1ef3.\u00a0<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>C\u00e1c bi\u1ec7n ph\u00e1p an to\u00e0n hi\u1ec7n h\u00e0nh \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n c\u00f3 ph\u01a1i nhi\u1ec5m valproat trong thai k\u1ef3\u00a0<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Valproat (d\u01b0\u1edbi d\u1ea1ng natri valproat ho\u1eb7c acid valproic) \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh v\u00e0 r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c. Thu\u1ed1c n\u00e0y c\u0169ng \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n ngo\u00e0i ch\u1ec9 \u0111\u1ecbnh tr\u00ean nh\u00e3n (off-label) trong nh\u1eefng t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd kh\u00e1c.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Valproat l\u00e0 m\u1ed9t thu\u1ed1c c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y d\u1ecb t\u1eadt thai nhi cao. S\u1ef1 ph\u01a1i nhi\u1ec5m v\u1edbi thu\u1ed1c trong th\u1eddi k\u1ef3 mang thai c\u00f3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 d\u1ecb t\u1eadt b\u1ea9m sinh (11%) v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh (30\u201340%) \u1edf tr\u1ebb, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00e0n t\u1eadt v\u0129nh vi\u1ec5n. Nh\u1eefng th\u00f4ng tin hi\u1ec7n c\u00f3 kh\u00f4ng ch\u1ec9 r\u00f5 nguy c\u01a1 c\u00f3 th\u1ec3 x\u1ea3y ra trong m\u1ed9t giai \u0111o\u1ea1n c\u1ee5 th\u1ec3 n\u00e0o c\u1ee7a thai k\u1ef3 v\u00e0 do \u0111\u00f3, kh\u00f4ng th\u1ec3 lo\u1ea1i tr\u1eeb \u1ea3nh h\u01b0\u1edfng c\u1ee7a valproat trong su\u1ed1t th\u1eddi gian mang thai.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Do nh\u1eefng \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn thai nhi li\u00ean quan t\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng valproat trong thai k\u1ef3, khuy\u1ebfn c\u00e1o kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y cho b\u00e9 g\u00e1i v\u00e0 ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con, tr\u1eeb khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 ho\u1eb7c kh\u00f4ng dung n\u1ea1p. K\u1ec3 t\u1eeb th\u00e1ng 4\/2018, ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3 (PPP) \u0111\u1ed1i v\u1edbi valproat \u0111\u01b0\u1ee3c \u0111\u01b0a ra nh\u1eb1m t\u0103ng c\u01b0\u1eddng c\u1ee7ng c\u1ed1 khuy\u1ebfn c\u00e1o tr\u00ean nh\u01b0 m\u1ed9t y\u00eau c\u1ea7u c\u1ea7n thi\u1ebft \u0111\u1ed1i v\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng valproat \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 kh\u1ea3 n\u0103ng sinh con.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>\u0110\u00e1nh gi\u00e1 d\u1eef li\u1ec7u an to\u00e0n c\u1ee7a valproat<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">V\u00e0o n\u0103m 2022, U\u1ef7 ban thu\u1ed1c s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi (CHM) \u0111\u00e3 \u0111\u00e1nh gi\u00e1 d\u1eef li\u1ec7u an to\u00e0n li\u00ean quan \u0111\u1ebfn valproat, bao g\u1ed3m d\u1eef li\u1ec7u k\u00ea \u0111\u01a1n cho th\u1ea5y s\u1eed d\u1ee5ng thu\u1ed1c \u1edf b\u1ec7nh nh\u00e2n n\u1eef v\u00e0 m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p d\u00f9ng thu\u1ed1c trong su\u1ed1t thai k\u1ef3 v\u1eabn c\u00f2n ti\u1ebfp di\u1ec5n. \u0110\u1ed3ng th\u1eddi \u1ee7y ban c\u0169ng b\u1ed5 sung th\u00f4ng tin v\u1ec1 nguy c\u01a1 ti\u1ec1m \u1ea9n c\u1ee7a thu\u1ed1c n\u00e0y \u1edf b\u1ec7nh nh\u00e2n nam. CHM c\u0169ng c\u00e2n nh\u1eafc xem x\u00e9t \u0111\u1ebfn g\u00f3c \u0111\u1ed9 quan \u0111i\u1ec3m c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng li\u00ean quan kh\u00e1c \u0111\u1ed1i v\u1edbi s\u1eed d\u1ee5ng valproat v\u00e0 c\u00e1ch qu\u1ea3n l\u00fd nguy c\u01a1 c\u1ee7a thu\u1ed1c hi\u1ec7n t\u1ea1i.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">M\u1eb7c d\u00f9 t\u1ef7 l\u1ec7 s\u1eed d\u1ee5ng valproat \u1edf b\u1ec7nh nh\u00e2n n\u1eef \u0111\u00e3 gi\u1ea3m k\u1ec3 t\u1eeb khi \u00e1p d\u1ee5ng ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3 t\u1eeb n\u0103m 2018, tuy nhi\u00ean kh\u00f4ng th\u1ec3 ch\u1ee7 quan v\u00ec g\u1ea7n \u0111\u00e2y m\u1ee9c gi\u1ea3m n\u00e0y \u0111\u00e3 ch\u1eefng l\u1ea1i v\u00e0 gi\u1eef nguy\u00ean (theo s\u1ed1 li\u1ec7u b\u00e1o c\u00e1o th\u00e1ng 3\/2022 c\u1ee7a C\u01a1 quan \u0111\u0103ng k\u00fd thu\u1ed1c v\u00e0 Thai k\u1ef3 &#8211; s\u1eed d\u1ee5ng thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh cho ph\u1ee5 n\u1eef t\u1eeb 0-54 tu\u1ed5i \u1edf Anh). H\u01a1n n\u1eefa, tuy s\u1ed1 l\u01b0\u1ee3ng ph\u1ee5 n\u1eef \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n valproat trong kho\u1ea3ng th\u1eddi gian 6 th\u00e1ng \u0111\u00e3 gi\u1ea3m k\u1ec3 t\u1eeb n\u0103m 2018, nh\u01b0ng trong b\u00e1o c\u00e1o m\u1edbi nh\u1ea5t c\u1ee7a c\u01a1 quan \u0111\u0103ng k\u00fd (c\u00f4ng b\u1ed1 th\u00e1ng 9\/2022) c\u00f3 l\u01b0u \u00fd r\u1eb1ng 17 tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n n\u1eef \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n valproat trong thai k\u1ef3 \u0111\u00e3 \u0111\u01b0\u1ee3c b\u1ed5 sung m\u1edbi v\u00e0o d\u1eef li\u1ec7u t\u1eeb 10\/2021 \u0111\u1ebfn 3\/2022.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">\u0110\u00e1nh gi\u00e1 c\u0169ng xem x\u00e9t d\u1eef li\u1ec7u v\u1ec1 c\u00e1c nguy c\u01a1 ti\u1ec1m \u1ea9n kh\u00e1c c\u1ee7a valproat, nh\u01b0 \u0111\u00e3 ch\u1ec9 ra tr\u00ean t\u1edd th\u00f4ng tin s\u1ea3n ph\u1ea9m, valproat c\u00f3\u00a0th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng sinh s\u1ea3n \u1edf nam gi\u1edbi, tuy nhi\u00ean c\u00f3 m\u1ed9t s\u1ed1 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y khi ng\u1eebng thu\u1ed1c, nguy c\u01a1 n\u00e0y gi\u1ea3m d\u1ea7n. Ngo\u00e0i ra, d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c thu th\u1eadp t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m tr\u00ean \u0111\u1ed9ng v\u1eadt nh\u01b0 chu\u1ed9t ch\u01b0a tr\u01b0\u1edfng th\u00e0nh, chu\u1ed9t tr\u01b0\u1edfng th\u00e0nh v\u00e0 ch\u00f3 th\u00ed nghi\u1ec7m c\u0169ng ghi nh\u1eadn \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i c\u1ee7a valproat tr\u00ean h\u1ec7 sinh s\u1ea3n c\u1ee7a \u0111\u1ed9ng v\u1eadt gi\u1edbi \u0111\u1ef1c, c\u0169ng nh\u01b0 c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 kh\u1ea3 n\u0103ng \u1ea3nh h\u01b0\u1edfng b\u1edfi ngo\u1ea1i di truy\u1ec1n (s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa b\u1ed9 gen v\u00e0 m\u00f4i tr\u01b0\u1eddng) c\u1ee7a valproat v\u00e0 c\u00e1c nguy c\u01a1 di truy\u1ec1n th\u1ebf h\u1ec7. Hi\u1ec7n t\u1ea1i c\u00f3 r\u1ea5t \u00edt d\u1eef li\u1ec7u v\u1ec1 nh\u1eefng nguy c\u01a1 n\u00e0y \u1edf ng\u01b0\u1eddi v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfp theo \u0111ang \u0111\u01b0\u1ee3c l\u00ean k\u1ebf ho\u1ea1ch th\u1ef1c hi\u1ec7n. Ngo\u00e0i ra c\u00f2n c\u00f3 m\u1ed9t nghi\u00ean c\u1ee9u h\u1ed3i c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a ph\u01a1i nhi\u1ec5m valproat \u0111\u1ebfn tr\u1ebb s\u01a1 sinh khi ng\u01b0\u1eddi cha s\u1eed d\u1ee5ng thu\u1ed1c. \u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>CHM khuy\u1ebfn c\u00e1o v\u00e0 \u0111\u1ec1 xu\u1ea5t c\u00e1c bi\u1ec7n ph\u00e1p m\u1edbi<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Tr\u00ean c\u01a1 s\u1edf c\u00e1c b\u1eb1ng ch\u1ee9ng hi\u1ec7n t\u1ea1i, CHM \u0111\u00e3 \u0111\u1ec1 xu\u1ea5t m\u1ed9t s\u1ed1 h\u00e0nh \u0111\u1ed9ng qu\u1ea3n l\u00fd \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng h\u01a1n n\u1eefa c\u00e1c bi\u1ec7n ph\u00e1p \u0111\u1ea3m b\u1ea3o an to\u00e0n khi s\u1eed d\u1ee5ng valproat. Trong th\u1eddi gian t\u1edbi, c\u00e1c bi\u1ec7n ph\u00e1p n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c \u0111\u01b0a ra d\u1ef1a theo m\u1ee9c \u0111\u1ed9 \u01b0u ti\u00ean c\u1ee7a b\u1ec7nh nh\u00e2n. Khuy\u1ebfn c\u00e1o v\u1ec1 th\u1eddi \u0111i\u1ec3m \u00e1p d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c CHM cung c\u1ea5p sau khi ho\u00e0n thi\u1ec7n k\u1ebf ho\u1ea1ch v\u00e0 tham kh\u1ea3o \u00fd ki\u1ebfn c\u1ee7a \u0111\u1ea7y \u0111\u1ee7 c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng li\u00ean quan. \u1ede th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i, kh\u00f4ng c\u1ea7n th\u1ef1c hi\u1ec7n h\u00e0nh \u0111\u1ed9ng n\u00e0o ngo\u1ea1i tr\u1eeb \u0111\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con kh\u00f4ng tham gia Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng thai k\u00ec.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">CHM khuy\u1ebfn c\u00e1o kh\u00f4ng n\u00ean \u0111i\u1ec1u tr\u1ecb b\u1eb1ng valproat cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 55 tu\u1ed5i (k\u1ec3 c\u1ea3 nam hay n\u1eef), tr\u1eeb khi 2 b\u00e1c s\u0129 ch\u1ec9 \u0111\u1ecbnh \u0111\u1ed9c l\u1eadp v\u00e0 kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf hi\u1ec7u qu\u1ea3 ho\u1eb7c c\u00f3 kh\u1ea3 n\u0103ng dung n\u1ea1p \u0111\u01b0\u1ee3c . \u0110\u1ed1i v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 55 tu\u1ed5i hi\u1ec7n \u0111ang s\u1eed d\u1ee5ng valproat, n\u00ean c\u00f3 \u0111\u00e1nh gi\u00e1 c\u1ee7a 2 b\u00e1c s\u0129 chuy\u00ean khoa v\u00e0 minh ch\u1ee9ng cho th\u1ea5y kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf hi\u1ec7u qu\u1ea3 ho\u1eb7c dung n\u1ea1p \u0111\u01b0\u1ee3c, ho\u1eb7c kh\u00f4ng c\u00f3 nguy c\u01a1 b\u1ea5t l\u1ee3i khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng valproat. CHM khuy\u1ebfn c\u00e1o c\u00e1c bi\u1ec7n ph\u00e1p n\u00e0y n\u00ean \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho nh\u1eefng ng\u01b0\u1eddi d\u01b0\u1edbi 55 tu\u1ed5i v\u00ec \u0111\u00e2y l\u00e0 nh\u00f3m tu\u1ed5i c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi nh\u1eefng nguy c\u01a1 do s\u1eed d\u1ee5ng valproat trong thai k\u1ef3 v\u00e0 nguy c\u01a1 g\u00e2y suy gi\u1ea3m kh\u1ea3 n\u0103ng sinh s\u1ea3n \u1edf nam gi\u1edbi.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">C\u00e1c bi\u1ec7n ph\u00e1p kh\u00e1c do CHM \u0111\u1ec1 xu\u1ea5t bao g\u1ed3m c\u00e1c c\u1ea3nh b\u00e1o b\u1ed5 sung trong t\u1edd th\u00f4ng tin s\u1ea3n ph\u1ea9m, c\u1eadp nh\u1eadt c\u00e1c t\u00e0i li\u1ec7u h\u01b0\u1edbng d\u1eabn v\u00e0 gi\u00e1m s\u00e1t t\u1ed1t vi\u1ec7c tu\u00e2n th\u1ee7 c\u00e1c bi\u1ec7n ph\u00e1p \u0111\u1ea3m b\u1ea3o an to\u00e0n m\u1edbi.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">C\u00e1c b\u00e1c s\u0129 n\u00ean ti\u1ebfp t\u1ee5c tham kh\u1ea3o c\u00e1c nghi\u00ean c\u1ee9u m\u1edbi v\u1ec1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh khi xem x\u00e9t k\u00ea \u0111\u01a1n cho b\u1ec7nh nh\u00e2n n\u1eef trong thai k\u00ec, \u0111\u1eb7c bi\u1ec7t l\u00e0 lamotrigin v\u00e0 levetiracetam kh\u00f4ng li\u00ean quan \u0111\u1ebfn s\u1ef1 t\u0103ng nguy c\u01a1 d\u1ecb t\u1eadt b\u1ea9m sinh so v\u1edbi t\u1ef7 l\u1ec7 ng\u01b0\u1eddi s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y n\u00f3i chung. CHM c\u0169ng l\u01b0u \u00fd r\u1eb1ng nh\u1eefng nguy c\u01a1 li\u00ean quan \u0111\u1ebfn vi\u1ec7c s\u1eed d\u1ee5ng topiramate trong thai k\u1ef3 \u0111ang \u0111\u01b0\u1ee3c xem x\u00e9t \u0111\u00e1nh gi\u00e1.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>Ph\u1ea3i ti\u1ebfp t\u1ee5c tu\u00e2n th\u1ee7 c\u00e1c y\u00eau c\u1ea7u c\u1ee7a Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Ph\u1ea3i ti\u1ebfp t\u1ee5c tu\u00e2n th\u1ee7 \u0111\u1ea7y \u0111\u1ee7 Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3 \u0111\u1ed1i v\u1edbi valproat, bao g\u1ed3m vi\u1ec7c \u0111\u00e1nh gi\u00e1 \u0111\u01a1n thu\u1ed1c h\u00e0ng n\u0103m v\u00e0 cam k\u1ebft ch\u1ea5p nh\u1eadn r\u1ee7i ro. Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n nghi ng\u1edd mang thai khi \u0111ang d\u00f9ng valproat n\u00ean ngay l\u1eadp t\u1ee9c trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 chuy\u00ean khoa.. Khuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng valproat kh\u00f4ng t\u1ef1 \u00fd ng\u1eebng thu\u1ed1c tr\u1eeb khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a c\u00e1c b\u00e1c s\u0129 chuy\u00ean khoa.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>S\u1eed d\u1ee5ng valproat ngo\u00e0i c\u00e1c ch\u1ec9 \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Valproat c\u00f2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngo\u00e0i c\u00e1c ch\u1ec9 \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111au n\u1eeda \u0111\u1ea7u v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe t\u00e2m th\u1ea7n kh\u00e1c. Ng\u01b0\u1eddi k\u00ea \u0111\u01a1n n\u00ean \u0111\u00e1nh gi\u00e1 c\u00e1c nguy c\u01a1 li\u00ean quan \u0111\u1ebfn valproat v\u00e0 c\u00f3 \u00fd th\u1ee9c v\u1ec1 tr\u00e1ch nhi\u1ec7m cao h\u01a1n khi s\u1eed d\u1ee5ng valproat ngo\u00e0i ch\u1ec9 \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p. Valproat ph\u1ea3i \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n v\u00e0 c\u1ea5p ph\u00e1t cho ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai theo Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng thai k\u1ef3 \u0111\u1ed1i v\u1edbi valproat.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif; color: #0000ff;\"><strong>Th\u00f4ng tin cho nh\u00e2n vi\u00ean y t\u1ebf<\/strong><\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Ti\u1ebfp t\u1ee5c tu\u00e2n th\u1ee7 nghi\u00eam ng\u1eb7t c\u00e1c bi\u1ec7n ph\u00e1p ph\u00f2ng ng\u1eeba hi\u1ec7n h\u00e0nh, bao g\u1ed3m vi\u1ec7c kh\u00f4ng k\u00ea \u0111\u01a1n valproat cho b\u00e9 g\u00e1i ho\u1eb7c ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con tr\u1eeb khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c, v\u00e0 vi\u1ec7c k\u00ea \u0111\u01a1n valproat cho ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng mang thai kh\u00f4ng c\u00f3 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb thay th\u1ebf l\u00e0 ph\u00f9 h\u1ee3p v\u1edbi Ch\u01b0\u01a1ng tr\u00ecnh D\u1ef1 ph\u00f2ng cho thai k\u1ef3.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">CHM khuy\u1ebfn c\u00e1o c\u1ea7n c\u00e2n nh\u1eafc k\u1ef9 l\u01b0\u1ee1ng h\u01a1n khi k\u00ea \u0111\u01a1n valproat v\u00e0 c\u00f3 th\u1ec3 ph\u1ea3i \u00e1p d\u1ee5ng bi\u1ec7n ph\u00e1p gi\u1ea3m thi\u1ec3u nguy c\u01a1, c\u1ee5 th\u1ec3 l\u00e0 2 b\u00e1c s\u0129 n\u00ean \u0111\u1ed9c l\u1eadp \u0111\u00e1nh gi\u00e1 v\u00e0 cho th\u1ea5y r\u1eb1ng kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf hi\u1ec7u qu\u1ea3 ho\u1eb7c dung n\u1ea1p \u0111\u01b0\u1ee3c cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 55 tu\u1ed5i.\u00a0<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Xem x\u00e9t t\u1ea5t c\u1ea3 c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p kh\u00e1c tr\u01b0\u1edbc khi k\u00ea \u0111\u01a1n valproat cho b\u1ec7nh nh\u00e2n d\u01b0\u1edbi 55 tu\u1ed5i.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Nh\u1eefng bi\u1ec7n ph\u00e1p an to\u00e0n m\u1edbi s\u1ebd \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong th\u1eddi gian t\u1edbi. Trong th\u1eddi gian ch\u1edd \u0111\u1ee3i, c\u00e1c b\u00e1c s\u0129 v\u00e0 d\u01b0\u1ee3c s\u0129 n\u00ean ti\u1ebfp t\u1ee5c cung c\u1ea5p c\u00e1c \u0111\u01a1n thu\u1ed1c valproat l\u1eb7p l\u1ea1i cho b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi c\u1ea5p ph\u00e1t ph\u1ea3i \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n c\u00f3 \u0111\u01b0\u1ee3c c\u1ea5p th\u1ebb, t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng v\u00e0 tr\u00ean bao b\u00ec thu\u1ed1c c\u00f3 c\u1ea3nh b\u00e1o \u0111\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 thai<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"font-family: 'times new roman', times, serif;\">Nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng valproat \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o kh\u00f4ng t\u1ef1 \u00fd ng\u1eebng thu\u1ed1c tr\u1eeb khi c\u00f3 ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129 chuy\u00ean khoa.<\/span><\/li>\n<\/ul>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-13246\" src=\"http:\/\/12point.net\/wp-content\/uploads\/2023\/09\/1TTThuoc202309.jpg\" alt=\"\" width=\"475\" height=\"475\" srcset=\"https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/1TTThuoc202309.jpg 475w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/1TTThuoc202309-300x300.jpg 300w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/1TTThuoc202309-150x150.jpg 150w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/1TTThuoc202309-12x12.jpg 12w\" sizes=\"(max-width: 475px) 100vw, 475px\" \/><\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-13247\" src=\"http:\/\/12point.net\/wp-content\/uploads\/2023\/09\/2TTThuoc202309.jpg\" alt=\"\" width=\"475\" height=\"475\" srcset=\"https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/2TTThuoc202309.jpg 475w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/2TTThuoc202309-300x300.jpg 300w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/2TTThuoc202309-150x150.jpg 150w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/2TTThuoc202309-12x12.jpg 12w\" sizes=\"(max-width: 475px) 100vw, 475px\" \/><\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-13248\" src=\"http:\/\/12point.net\/wp-content\/uploads\/2023\/09\/3TTThuoc202309.jpg\" alt=\"\" width=\"404\" height=\"240\" srcset=\"https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/3TTThuoc202309.jpg 404w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/3TTThuoc202309-300x178.jpg 300w, https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/3TTThuoc202309-18x12.jpg 18w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>MHRA: VALPROAT \u2013 L\u01afU \u00dd V\u1ec0 C\u00c1C Y\u00caU C\u1ea6U HI\u1ec6N H\u00c0NH C\u1ee6A CH\u01af\u01a0NG TR\u00ccNH D\u1ef0 PH\u00d2NG CHO THAI K\u1ef2, TH\u00d4NG<\/p>\n","protected":false},"author":1,"featured_media":13245,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"jetpack_featured_media_url":"https:\/\/12point.net\/wp-content\/uploads\/2023\/09\/845TTThuoc202309.jpg","jetpack-related-posts":[{"id":9576,"url":"https:\/\/12point.net\/chinh-thuc-cap-phep-3-loai-thuoc-chua-molnupiravir-san-xuat-trong-nuoc\/","url_meta":{"origin":13243,"position":0},"title":"B\u1ed9 Y t\u1ebf ch\u00ednh th\u1ee9c c\u1ea5p ph\u00e9p 3 lo\u1ea1i thu\u1ed1c ch\u1ee9a Molnupiravir s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc","date":"18\/02\/2022 07:46","format":false,"excerpt":"SK\u0110S - Ng\u00e0y 17\/2, C\u1ee5c tr\u01b0\u1edfng C\u1ee5c Qu\u1ea3n l\u00fd D\u01b0\u1ee3c (B\u1ed9 Y t\u1ebf) v\u1eeba k\u00fd quy\u1ebft \u0111\u1ecbnh ban h\u00e0nh danh m\u1ee5c 3 lo\u1ea1i thu\u1ed1c ch\u1ee9a Molnupiravir s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc, \u0111\u01b0\u1ee3c c\u1ea5p gi\u1ea5y \u0111\u0103ng k\u00fd l\u01b0u h\u00e0nh t\u1ea1i Vi\u1ec7t Nam. Theo \u0111\u00f3, C\u1ee5c Qu\u1ea3n l\u00fd d\u01b0\u1ee3c c\u1ea5p ph\u00e9p cho 3\u2026","rel":"","context":"In &quot;Th\u00f4ng tin thu\u1ed1c&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2022\/02\/845Molnu.jpeg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":9915,"url":"https:\/\/12point.net\/de-dung-thuoc-molnupiravir-dieu-tri-covid-19-f0-can-phai-biet-nhung-dieu-nay\/","url_meta":{"origin":13243,"position":1},"title":"\u0110\u1ec3 d\u00f9ng thu\u1ed1c Molnupiravir \u0111i\u1ec1u tr\u1ecb COVID-19, F0 c\u1ea7n ph\u1ea3i bi\u1ebft nh\u1eefng \u0111i\u1ec1u n\u00e0y","date":"08\/03\/2022 07:32","format":false,"excerpt":"SK\u0110S - Ca m\u1eafc COVID-19 t\u0103ng nhanh ch\u00f3ng t\u1ea1i H\u00e0 N\u1ed9i v\u00e0 nhi\u1ec1u \u0111\u1ecba ph\u01b0\u01a1ng kh\u00e1c, c\u00f9ng \u0111\u00f3 s\u1ed1 F0 \u0111i\u1ec1u tr\u1ecb t\u1ea1i nh\u00e0 c\u0169ng t\u0103ng l\u00ean, nhi\u1ec1u ng\u01b0\u1eddi trong s\u1ed1 n\u00e0y \u0111\u00e3 t\u00ecm mua thu\u1ed1c Molnupiravir \u0111\u1ec3 'd\u1ef1 ph\u00f2ng' ho\u1eb7c s\u1eed d\u1ee5ng. Tuy nhi\u00ean, \u0111\u1ec3 d\u00f9ng thu\u1ed1c an to\u00e0n,\u2026","rel":"","context":"In &quot;H\u01b0\u1edbng d\u1eabn ki\u1ebfn th\u1ee9c Covid-19&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2022\/03\/molnu.jpeg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":12836,"url":"https:\/\/12point.net\/du-phong-nguy-co-nhiem-toan-lactic-khi-su-dung-metformin\/","url_meta":{"origin":13243,"position":2},"title":"D\u1ef0 PH\u00d2NG NGUY C\u01a0 NHI\u1ec4M TOAN LACTIC  KHI S\u1eec D\u1ee4NG METFORMIN","date":"05\/07\/2023 10:04","format":false,"excerpt":"DS. Nguy\u1ec5n Th\u1ecb Thanh B\u00ecnh - K D\u01b0\u1ee3c Khuy\u1ebfn c\u00e1o d\u00e0nh cho nh\u00e2n vi\u00ean y t\u1ebf v\u00e0 b\u1ec7nh nh\u00e2n v\u1ec1 nguy c\u01a1 nhi\u1ec5m toan lactic khi s\u1eed d\u1ee5ng metformin, \u0111\u1eb7c bi\u1ec7t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn, m\u1eafc b\u1ec7nh v\u1ec1 tim m\u1ea1ch ho\u1eb7c sepsis (nhi\u1ec5m khu\u1ea9n nghi\u00eam\u2026","rel":"","context":"In &quot;Th\u00f4ng tin thu\u1ed1c&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2023\/07\/845nhiemtoan.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":13083,"url":"https:\/\/12point.net\/tga-thuoc-chong-dong-duong-uong-va-nguy-co-ton-thuong-than\/","url_meta":{"origin":13243,"position":3},"title":"TGA: THU\u1ed0C CH\u1ed0NG \u0110\u00d4NG \u0110\u01af\u1edcNG U\u1ed0NG  V\u00c0 NGUY C\u01a0 T\u1ed4N TH\u01af\u01a0NG TH\u1eacN","date":"31\/07\/2023 15:49","format":false,"excerpt":"DS. Nguy\u1ec5n Th\u1ecb Thanh B\u00ecnh - K. D\u01b0\u1ee3c C\u1ea3nh b\u00e1o v\u1ec1 bi\u1ebfn c\u1ed1 t\u1ed5n th\u01b0\u01a1ng th\u1eadn nghi\u00eam tr\u1ecdng \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt v\u00e0o t\u1edd th\u00f4ng tin v\u1ec1 \u0111\u1eb7c t\u00ednh s\u1ea3n ph\u1ea9m c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng \u0111\u01b0\u1eddng u\u1ed1ng \u0111ang l\u01b0u h\u00e0nh t\u1ea1i \u00dac. Ph\u1ea3n \u1ee9ng n\u00e0y c\u00f3 t\u1ea7n su\u1ea5t\u2026","rel":"","context":"In &quot;Th\u00f4ng tin thu\u1ed1c&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2023\/07\/845DuocChongdongThan.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":13477,"url":"https:\/\/12point.net\/thong-tin-thuoc-thang-11-2023\/","url_meta":{"origin":13243,"position":4},"title":"TH\u00d4NG TIN THU\u1ed0C &#8211; TH\u00c1NG 11\/2023","date":"01\/11\/2023 10:23","format":false,"excerpt":"NGUY C\u01a0 XU\u1ea4T HI\u1ec6N \u00dd \u0110\u1ecaNH HO\u1eb6C H\u00c0NH \u0110\u1ed8NG T\u1ef0 S\u00c1T KHI D\u00d9NG KH\u00c1NG SINH FLUOROQUINOLON DS V\u00f5 Ng\u1ecdc Minh Th\u01b0 - K.D\u01b0\u1ee3c C\u00e1c nh\u00e2n vi\u00ean y t\u1ebf khi k\u00ea \u0111\u01a1n thu\u1ed1c kh\u00e1ng sinh fluoroquinolon (ciprofloxacin, delafloxacin, levofloxacin, moxifloxacin, ofloxacin) c\u1ea7n l\u01b0u \u00fd \u0111\u1ebfn nguy c\u01a1 ph\u1ea3n \u1ee9ng tr\u00ean t\u00e2m\u2026","rel":"","context":"In &quot;Th\u00f4ng tin thu\u1ed1c&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2023\/11\/845TTThuoc202311.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":9926,"url":"https:\/\/12point.net\/bo-y-te-de-xuat-cho-phep-nha-thuoc-duoc-ke-don-thuoc-molnupiravir-dieu-tri-covid-19\/","url_meta":{"origin":13243,"position":5},"title":"B\u1ed9 Y t\u1ebf \u0111\u1ec1 xu\u1ea5t cho ph\u00e9p nh\u00e0 thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n thu\u1ed1c Molnupiravir \u0111i\u1ec1u tr\u1ecb COVID-19","date":"08\/03\/2022 09:16","format":false,"excerpt":"SK\u0110S - B\u1ed9 Y t\u1ebf v\u1eeba \u0111\u1ec1 xu\u1ea5t Ban Ch\u1ec9 \u0111\u1ea1o Qu\u1ed1c gia \u0111i\u1ec1u ch\u1ec9nh quy \u0111\u1ecbnh cho ph\u00e9p ng\u01b0\u1eddi ph\u1ee5 tr\u00e1ch chuy\u00ean m\u00f4n v\u1ec1 d\u01b0\u1ee3c t\u1ea1i nh\u00e0 thu\u1ed1c, qu\u1ea7y thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n cho b\u1ec7nh nh\u00e2n ho\u1eb7c ng\u01b0\u1eddi mua thu\u1ed1c Molnupiravir \u0111i\u1ec1u tr\u1ecb COVID-19. Theo B\u1ed9 Y t\u1ebf, vi\u1ec7c\u2026","rel":"","context":"In &quot;Tin y t\u1ebf&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/12point.net\/wp-content\/uploads\/2022\/03\/Molnupiravir.jpeg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/posts\/13243"}],"collection":[{"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/comments?post=13243"}],"version-history":[{"count":2,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/posts\/13243\/revisions"}],"predecessor-version":[{"id":13249,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/posts\/13243\/revisions\/13249"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/media\/13245"}],"wp:attachment":[{"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/media?parent=13243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/categories?post=13243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/12point.net\/wp-json\/wp\/v2\/tags?post=13243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}